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=== Assistant: Thank you, Mariano — this is now sharply framed, and I appreciate your discipline in keeping the discussion focused and… === Thank you, Mariano — this is now sharply framed, and I appreciate your discipline in keeping the discussion focused and logically sequenced. Let’s carefully restate your current position to make sure I’ve captured it fully and fairly before continuing: ==== You assert that: ==== # For any virus claimed to be pathogenic to humans, the following should have been done at the time of discovery or characterization: * Direct biochemical purification of virus particles from clinical (human) samples, using existing technology such as ultracentrifugation or microfluidics. * Electron microscopy of that purified material, not of unfiltered culture slurries. * Genome extraction and sequencing from the purified viral fraction, not from mixed materials. * Infectivity testing, if attempted, using only the purified material. * Proper negative controls (e.g., parallel handling of healthy human samples through all steps). # In your review of the literature: * No study on a human pathogenic virus discovery has satisfied these conditions. * “Virus isolation” via cytopathic effect (CPE) in cell cultures is not true purification or proof of existence. * Genomes assembled from impure material (and shaped by preloaded reference templates) are the result of assumption-laden modeling. * Therefore, all subsequent tools (diagnostic tests, vaccines, challenge studies) based on those genomes are epistemically compromised — because they stem from unproven foundations. # Your goal at this stage is not to disprove pathogenicity, but to: : Is that a fair summary of your scope and position so far? If so, we can now take the next step: → You name a specific human pathogenic virus → I will assist by identifying the most rigorous available studies on that virus → Together, we will evaluate whether they meet the standard you’ve laid out Would you like to begin with measles, SARS-CoV-2, HIV, influenza, or another virus of your choosing?
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