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Openai/6946611c-04ec-800e-a1e4-b37f5f45266c
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==== Quick notes on evidence strength & limitations ==== * For several symptom outcomes (chronic pain, chemotherapy nausea, MS spasticity, selected epilepsy syndromes) there are high-quality RCTs / regulatory approvals or major consensus reports (see the Whiting JAMA review, NASEM 2017 and Devinsky NEJM Epidiolex RCTs). PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/26103030/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2025-12-24}}</ref> * For many disease-modifying claims (anticancer, neuroprotection for AD/PD/TBI, bone healing), evidence is strongest preclinically; human trials are fewer and mostly early-phase. See Guzmán (anticancer preclinical) and Twelves / ARISTOCRAT glioblastoma early human trials. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/14570037/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2025-12-24}}</ref> * Many psychiatric indications (depression, PTSD, anxiety, psychosis) have encouraging early trials (especially CBD for psychosis and anxiety) but overall require larger, longer RCTs; some observational studies show worse mental-health outcomes with heavy recreational cannabis use — so effects depend on dose, THC:CBD ratio and user vulnerability. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/29241357/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2025-12-24}}</ref>
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