Editing Openai/686aedb2-60b0-8003-98a8-e1766cf496a6 (section)

===== - Peer-reviewed rebuttals specifically targeting their differential-equation analysis have not (yet) appeared in the literature up to mid-2025. Their follow-up papers in Molecular Biology & Evolution (2018) and IJMS (2020) extend, rather than retract, the framework and have met mostly with interest, not demolition. =====
* Skeptical commentary does exist. Journalistic pieces (e.g., Quanta Magazine) note that the PRCW evidence is “purely computational” and stress that the RNA world still enjoys far more experimental support; several origin-of-life researchers quoted there regard any claim of formal falsification as premature quantamagazine.org<ref>{{cite web|title=quantamagazine.org|url=https://www.quantamagazine.org/the-end-of-the-rna-world-is-near-biochemists-argue-20171219/|publisher=quantamagazine.org|access-date=2025-11-16}}</ref>.
* Mainstream origin-of-life reviews since 2018 (e.g., “The difficult case of an RNA-only origin of life”, 2019) cite Wills & Carter as part of a growing peptide-RNA camp but treat their verdict as one hypothesis among several, not a settled matter. None mounts a point-by-point mathematical refutation.