Editing Openai/69585660-954c-8011-b9ec-bc5c70cfea17 (section)

===== 🔬 Supportive Research Findings =====
# Schulte et al. (2014): Iron in RLS treatment overview - Reports that low-normal ferritin (< 50 ng/mL) is often associated with more severe RLS and that oral iron benefits those with lower ferritin readings. - This paper cites several smaller studies showing response to iron therapy in RLS with low ferritin. PMC<ref>{{cite web|title=PMC|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC6183309/|publisher=pmc.ncbi.nlm.nih.gov|access-date=2026-01-03}}</ref>
# Wang et al. (2009) – RCT on oral iron for RLS - This randomized, placebo-controlled trial found that oral iron improved RLS symptoms in patients with low-normal ferritin levels compared with placebo, supporting targeting higher ferritin in treatment contexts. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/19230757/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2026-01-03}}</ref>
# Li et al. (2023) meta-analysis on low serum ferritin and RLS augmentation - Lower serum ferritin is shown to be associated with RLS augmentation (worsening symptoms due to treatment), supporting the idea that iron status relates to RLS severity. ScienceDirect<ref>{{cite web|title=ScienceDirect|url=https://www.sciencedirect.com/science/article/abs/pii/S1389945723004008|publisher=sciencedirect.com|access-date=2026-01-03}}</ref>