Editing Openai/69101fc6-f990-800a-9638-7716259af6c4 (section)

=== - Systemic inflammation (hs-CRP) ↓ small-to-moderate (curcumin meta-analyses show reductions, especially if CRP is high at baseline) Measure: hs-CRP blood test Why: curcuminoids down-regulate NF-κB and inflammatory cytokines. ClinicalTrials.gov<ref>{{cite web|title=ClinicalTrials.gov|url=https://clinicaltrials.gov/study/NCT04105504|publisher=clinicaltrials.gov|access-date=2025-11-09}}</ref> ===
* Glutathione/redox status ↑ (via NAC precursor + any added glutathione in your stack) Measure: RBC/whole-blood GSH, GSH:GSSG ratio Why: NAC provides cysteine to synthesize GSH; oral GSH also raises stores. Penn State<ref>{{cite web|title=Penn State|url=https://pure.psu.edu/en/publications/randomized-controlled-trial-of-oral-glutathione-supplementation-o|publisher=Penn State|access-date=2025-11-09}}</ref>PMC<ref>{{cite web|title=PMC|url=https://pmc.ncbi.nlm.nih.gov/articles/PMC8234027/|publisher=pmc.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>
* Liver enzymes (ALT/AST) ↓ in people with elevated enzymes/NAFLD in some trials of NAC/curcumin; minimal change if normal Measure: CMP panel Why: antioxidant/anti-inflammatory effects in hepatocytes. (General RCT evidence base; curcumin/NAC data support.)
* Glycemic control (if insulin-resistant/T2D): ginger/curcumin show small improvements; expect modest HbA1c/fasting glucose drops at 12+ weeks if elevated at baseline Measure: HbA1c; CGM/fasting glucose Why: improved insulin sensitivity and inflammation. PubMed<ref>{{cite web|title=PubMed|url=https://pubmed.ncbi.nlm.nih.gov/24318038/|publisher=pubmed.ncbi.nlm.nih.gov|access-date=2025-11-09}}</ref>