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==== ✅ Supplements that might help (with caveats) ==== Here are supplements commonly discussed for people under high cortisol / stress — or with Cushing-like symptoms. Use cautiously, especially with high blood pressure or other conditions. | Supplement / Nutrient | What it may help with / Why it’s considered | Important notes / cautions | | ------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------ | ------------------------------------------------------------------------------------------------------------------------ | | Magnesium (e.g. glycinate) | Helps nervous system relaxation, may improve sleep and stress tolerance; some sources suggest it helps modulate cortisol clearance. integrativewellnessfx.com +2 Jinfiniti Precision Medicine +2 | Too much magnesium can upset digestion or cause imbalances — dosage should be moderate and doctor-approved. Siris Health +1 | | Omega‑3 fatty acids (EPA/DHA — fish oil or algae-based) | Anti-inflammatory, supports heart/vascular health, may help blunt stress responses and improve mood. Practo +2 Forbes +2 | Quality matters — choose clean, reputable source; high doses can have side effects (e.g. on blood clotting). | | Vitamin C | Supports adrenal and immune function; antioxidant — may help with oxidative stress from chronic high cortisol. Practo +1 | In high doses may cause digestive upset; and effect on cortisol is modest. Siris Health +1 | | Vitamin D + Calcium (or calcium-rich diet) | Important for bone health; with Cushing’s there’s increased risk of bone thinning/osteoporosis. Institute for Natural Medicine +1 | Needs balance — excessive calcium/vitamin D without monitoring can be harmful; check blood levels if possible. | | Phosphatidylserine | Some evidence it may blunt stress-induced cortisol spikes and support cognition/mental focus. Practo +1 | Evidence is limited; benefit modest — shouldn’t be considered a “treatment.” | | Ashwagandha (adaptogenic herb) | In small studies among stressed people, associated with lower cortisol, better sleep and reduced anxiety. Jinfiniti Precision Medicine +1 | Because Cushing’s involves real hormonal imbalance, adaptogens are not a fix; some experts caution they may do little or be misleading. Siris Health +1 |
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